Virus Particles Under Electron Microscopy

Colorized images of various virus particles including hepatitis B, herpes simplex, bunyavirus, smallpox, and influenza, showcasing detailed structures captured through transmission electron microscopy

Colorized negatively-stained transmission electron micrograph of hepatitis B virus, HBV, virions, also know as Dane particles

Colorized negatively-stained transmission electron micrograph of hepatitis B virus, HBV, virions, also know as Dane particles

Herpes simplex virus 2 (HSV2). It causes genital herpes. HSV infection is a lifelong disease that causes repeated painful rashes. Transmission electron microscopy. Viral diameter: 180 nm.

Bunyavirus. Image produced using high-dynamic-range imaging (HDRI) from an image taken with transmission electron microscopy. Viral diameter around 100 nm.

Smallpox virus particles, TEM

Influenza virus. Influenza A virus causes flu in humans, swine, birds, horses and dogs. Which species the virus will infect is determined by the glycoprotein spikes on its outer envelope. They are many strains of influenza A virus, among which the avian flu virus (H5N1), swine flu (H1N1) or human. Transmission Electron Micrograph (TEM).

Transmission electron micrograph of cytomegalovirus (CMV) particles (pink) found within intracellular vesicles of an infected macrophage (teal).

This negatively-stained transmission electron micrograph (TEM) captured some of the ultrastructural details exhibited by the new influenza A (H7N9) virus. On April 1, 2013, the World Health Organization (WHO) first reported 3 human infections with a new influenza A (H7N9) virus in China. Since then, additional cases have been reported. Most reported cases have severe respiratory illness and, in some cases, have died. At this time, no cases of H7N9 outside of China have been reported. The new H7N9 virus has not been detected in people or birds in the United States. This new H7N9 virus is an avian (bird) influenza (flu) virus. Human infections with avian influenza (AI, or bird flu) are rare but have occurred in the past, most commonly after exposure to infected poultry. However, this is the first time that this bird flu subtype (H7N9) has been found in people. This virus is very different from other H7N9 viruses previously found in birds.

Transmission electron micrograph of dengue virus particles (gold).

Coronavirus (CoV). viruses of the Coronaviridae family and the Orthocoronavirinae subfamily. It is a pathogen of respiratory syndromes. Viewed from a transmission electron microscopy (TEM) image. Viral diameter 80nm to 100nm.

Scanning electron microscopic image of Smallpox virus highly contagious infectious disease

This colorized transmission electron micrograph (TEM) of an ultra-thin specimen revealed some of the ultrastructural morphologic features seen in 1918 influenza virus virions. The prominent surface projections on the virions are composed of either the hemagglutinin, or neuraminidase type of glycoproteins. Composed of what looked like dots or tubules, was a dense envelope known as a capsid, which surrounded each virion's nucleic acid constituents.

HPV (human papillomavirus). The human papillomavirus or HPV is the cause of sexually transmitted infections (genital warts that can induce cancer of the cervix). HPV is also the cause of skin warts. View taken from an electron microscope transmission. Viral diameter approximately 55 nm.

This colorized negative stained transmission electron micrograph (TEM) depicted some of the ultrastructural morphology of the A/CA/4/09 swine flu virus. Swine Influenza (swine flu) is a respiratory disease of pigs caused by type A influenza virus that regularly causes outbreaks of influenza in pigs. Swine flu viruses cause high levels of illness and low death rates in pigs. Swine influenza viruses may circulate among swine throughout the year, but most outbreaks occur during the late fall and winter months similar to outbreaks in humans. The classical swine flu virus (an influenza type A H1N1 virus) was first isolated from a pig in 1930.

An electron micrograph of the Norovirus, with 27-32nm-sized viral particles. Norwalk viruses (and related caliciviruses) are important causes of nonbacterial gastroenteritis in the United States. An estimated 181,000 cases of this type of food poisoning occur annually. See image n0120806 on the site.

Colorized transmission electron micrograph of HIV-1 virus particles (yellow and red) budding from the plasma membrane of an infected H9 T cell (burgundy).

Transmission electron micrograph of HIV-1 virus particles (colorized yellow) replicating from an HIV-infected H9 T-cell (pink).

Pasteurella multocida or Pasteurella septica is the bacillus involved in the infection of wounds by animal bites or scratches. After an incubation of a few hours appears a Pasteurellian phlegmon characterized by lymphangitis. Optical microscopy

Coronavirus (CoV). viruses of the Coronaviridae family and the Orthocoronavirinae subfamily. It is a pathogen of respiratory syndromes. Viewed from a transmission electron microscopy (TEM) image. Viral diameter 80nm to 100nm

Electron micrograph of the West Nile virus. This RNA virus is a flavivirus (flaviviridae) responsible for the West Nile fever.

Negatively-stained transmission electron micrograph of numerous herpes simplex virions, members of the Herpesviridae virus family

Herpes simplex virus 2 (HSV2). It causes genital herpes. HSV infection is a lifelong disease that causes repeated painful rashes. Transmission electron microscopy. Viral diameter: 180 nm.

Colorized transmission electron micrograph of monkeypox virus particles (yellow) cultivated and purified from cell culture

Adenovirus (highly contagious virus), responsible for: Colds, pharyngitis, bronchitis, pneumonia, gastroenteritis, conjunctivitis and keratitis. Image made from a transmission electron microscopy view.

Smallpox. Transmission electron micrograph (TEM) of variola viruses, magnification 310,000x. This DNA virus is a Poxvirus (genus orthopoxvirus) that causes smallpox.

This colorized transmission electron micrograph (TEM) depicts numbers of influenza A virions while in their late passage growth phase.

Colorized transmission electron micrograph of mpox virus particles (orange) found within an infected cell (brown), cultured in the laboratory.

Transmission electron micrograph (TEM) of variola viruses, magnification 370,000x. This DNA virus is a Poxvirus (genus orthopoxvirus) that causes smallpox.

Transmission electron micrograph of SARS-CoV-2 virus particles (yellow) within endosomes of a heavily infected nasal Olfactory Epithelial Cell. Image captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland.

Human papilloma virus (HPV). Image produced using high-dynamic-range imaging (HDRI) from an image taken with transmission electron microscopy. Viral diameter around 55 nm.

Rotavirus and other unknown 29nm virus particles. This electron micrograph reveals a number of RNA rotavirus virions, and a number of unknown, 29nm virion particles. A rotavirus has a characteristic wheel-like appearance when viewed by electron microscopy, ie rotavirus is derived from the Latin rota, meaning wheel. Rotaviruses are nonenveloped, double-shelled viruses, making the virus stable in the environment. See image n1302705 on the site.

Human immunodeficiency virus (HIV), the retrovirus responsible for AIDS. Image produced with transmission electron microscope (viral diameter ranges from around 110 to 125 nm).

This scanning electron microscope image shows SARS-CoV-2 (round red particles) emerging from the surface of a cell cultured in the laboratory. SARS-CoV-2, also known as 2019-nCoV, is the virus that causes COVID-19. Image captured and colorized at Rocky Mountain Laboratories in Hamilton, Montana. Credit: NIAID

Cytomegalovirus (human herpesvirus 5, HHV-5). It causes a dangerous mononucleosis syndrome especially in the immunocompromised. View taken with HDRI image processing from a transmission electron microscopy image. Viral diameter about 200 nm.

HPV (human papillomavirus). The human papillomavirus or HPV is the cause of sexually transmitted infections (genital warts that can induce cancer of the cervix). HPV is also the cause of skin warts. View taken from an electron microscope transmission. Viral diameter approximately 55 nm.

Roseolovirus (HHV 5 & 6). Image produced using high-dynamic-range imaging (HDRI) from an image taken with transmission electron microscopy. Viral diameter around 200 nm.

Coronavirus (CoV). viruses of the Coronaviridae family and the Orthocoronavirinae subfamily. It is a pathogen of respiratory syndromes. Viewed from a transmission electron microscopy (TEM) image. Viral diameter 80nm to 100nm.

Virus responsible for smallpox. A transmission electron micrograph of smallpox viruses. Smallpox is a serious, highly contagious, and sometimes fatal infectious disease. There is no specific treatment for smallpox disease, and the only prevention is vaccination. See image n0641905 on the site.

Transmission electron micrograph of cytomegalovirus (CMV) particles (red) found within intracellular vesicles of an infected macrophage (blue).

This colorized negative stained transmission electron micrograph (TEM) depicted some of the ultrastructural morphology of the A/CA/4/09 swine flu virus. Swine Influenza (swine flu) is a respiratory disease of pigs caused by type A influenza virus that regularly causes outbreaks of influenza in pigs. Swine flu viruses cause high levels of illness and low death rates in pigs. Swine influenza viruses may circulate among swine throughout the year, but most outbreaks occur during the late fall and winter months similar to outbreaks in humans. The classical swine flu virus (an influenza type A H1N1 virus) was first isolated from a pig in 1930.

Transmission electron micrograph of Middle East respiratory syndrome coronavirus particles, colorized in yellow. Credit: NIAID.

Influenza B virus particles, colorized gold, isolated from a patient sample and then propagated in cell culture. Both influenza A and B can cause seasonal flu however, unlike influenza A virus, which can also infect animals, influenza B only infects humans.

Novel Coronavirus SARS-CoV-2, causes 'coronavirus disease-2019', abbreviated as COVID-19. Transmission electron microscopic image of an isolate from the first US case of COVID-19. The spherical extracellular viral particles contain cross-sections through the viral genome, seen as black dots. Image by Centers for Disease Control and Prevention (CDC) (BSLOC_2020_2_249)

Influenza virus (Myxovirus influenzae) from the Orthomyxoviridae family. Viral diameter from 80 to 120 nanometers, taken using transmission electron microscopy.

Colorized transmission electron micrograph of a cross-section of SW31 (swine strain) influenza virus particles (orange) found near the surface of an infected MDCK cell (green). Image captured and color-enhanced at the NIAID Integrated Research Facility in Fort Detrick, Maryland. Credit: NIAID.

Hepatitis C virus (close to the Flavivirid family). HCV causes blood-borne hepatitis, cirrhosis occurs in 25% of cases, 10 to 20 years after the onset of infection, with a risk of hepatic carcinoma. View produced from a transmission electron microscopy image. Viral diameter approximately: 50 to 60 nm.

Scanning electron microscopic image of the dumbbell-shaped structure inside the smallpox virion is the viral core which contains the viral DNA

Transmission electron micrograph of hepatitis B virions also known as Dane particles.

Transmission electron micrograph of SARS-CoV-2 virus particles, isolated from a patient. Image captured and color-enhanced at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: NIAID.

Electron micrograph of the Rift Valley Fever virus. Rift Valley Fever (RVF) virus is a member of the genus Phlebovirus in the family Bunyaviridae, first reported in livestock in Kenya around 1900.

Transmission Electron Micrograph (TEM) of influenza virus particles. Influenza virus are RNA virus (Orthomyxovirus) including Influenza A and B, the two types of influenza viruses.

Negatively-stained transmission electron micrograph showing hepatitis B virus (HBV) virions

Transmission electron micrograph of SARS-CoV-2 virus particles (colorized gold), isolated from a patient sample.

Coronavirus (CoV). viruses of the Coronaviridae family and the Orthocoronavirinae subfamily. It is a pathogen of respiratory syndromes. Viewed from a transmission electron microscopy (TEM) image. Viral diameter 80nm to 100nm.

Colorized transmission electron micrograph of monkeypox virus particles (yellow) cultivated and purified from cell culture.

Electron micrograph of the West Nile virus. West Nile virus is a flavivirus commonly found in Africa, West Asia, and the Middle East. It is closely related to St. Louis encephalitis virus found in the United States

Transmission electron micrograph of Bacillus anthracis.

Hepatitis A virus (HAV). Image produced using high-dynamic-range imaging (HDRI) from an image taken with transmission electron microscopy. Viral diameter ranges from around 20 to 30 nm.

Epstein-Barr virus (human herpesvirus 4, HHV-4). It causes infectious mononucleosis and Burkitt's lymphoma. View taken with HDRI image processing from a transmission electron microscopy image. Viral diameter about 200 nm.

Hepatitis C virus (HCV). Image produced using high-dynamic-range imaging (HDRI) from an image taken with transmission electron microscopy. Viral diameter around 22 nm.

Flavivirus (family Flaviviridae), these viruses are responsible for yellow fever, dengue fever, Japanese encephalitis, Zika virus, West Nile encephalitis. They are transmitted by mosquitoes or ticks. image produced from transmission electron microscopy (viral diameter approximately 40 to 60 nm).

Transmission electron micrograph of a variant strain of SARS-CoV-2 virus particles (UK B.1.1.7), isolated from a patient sample and cultivated in cell culture. Image captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland.

This colorized negative stained transmission electron micrograph (TEM) depicted some of the ultrastructural morphology of the A/CA/4/09 swine flu virus. Swine Influenza (swine flu) is a respiratory disease of pigs caused by type A influenza virus that regularly causes outbreaks of influenza in pigs. Swine flu viruses cause high levels of illness and low death rates in pigs. Swine influenza viruses may circulate among swine throughout the year, but most outbreaks occur during the late fall and winter months similar to outbreaks in humans. The classical swine flu virus (an influenza type A H1N1 virus) was first isolated from a pig in 1930.

Hepatitis B virus (Hepadnavirid family). HBV causes sexually transmitted or blood-borne hepatitis. Cirrhosis occurs in 20% of cases 15 to 20 years after the onset of infection. Image made from transmission electron microscopy. Approximate viral diameter: 22 nm.

Transmission Electron Micrograph (TEM) of Spanish flu virus. This pandemic virus infected a fifth of the world population and killed between 20 and 50 million. This Influenza virus type a, strain H1N1 is very close to the swine flu (strain H1N1) and the avian flu virus (strain H5N1).

Negative-stained transmission electron micrograph depicts the ultrastructural details of a number of influenza virus particles

Haemophilus ducreyi, or Ducrey's bacillus, is transmitted by sexual contact (STD), it is an extremely contagious bacterium that does not provide immunity. It causes chancroid (or chancre or Ducrey's chancre), characterized by an ulcerated chancre associated with lymphadenopathy. Visualization by Optical Microscopy

This colorized transmission electron micrograph (TEM) depicts numbers of influenza A virions while in their late passage growth phase.

Hepatitis B virus (HBV). Image produced using high-dynamic-range imaging (HDRI) from an image taken with transmission electron microscopy. Viral diameter ranges from around 50 to 60 nm.

Flavivirus. Image produced using high-dynamic-range imaging (HDRI) from an image taken with transmission electron microscopy. Viral diameter around 35 nm.

This digitally-colorized transmission electron micrograph (TEM) depicts numerous Chikungunya virus particles, which are composed of a central dense core that is surrounded by a viral envelope. Each virion is approximately 50nm in diameter. Chikungunya virus is transmitted to people by mosquitoes. The most common symptoms of chikungunya virus infection are fever and joint pain. Other symptoms may include headache, muscle pain, joint swelling, or rash. Outbreaks have occurred in countries in Africa, Asia, Europe, and the Indian and Pacific Oceans. In late 2013, chikungunya virus was found for the first time in the Americas on islands in the Caribbean. Chikungunya virus is not currently found in the United States. There is a risk that the virus will be imported to new areas by infected travelers. There is no vaccine to prevent or medicine to treat chikungunya virus infection. Travelers can protect themselves by preventing mosquito bites. When traveling to countries with chikungunya virus,

Transmission electron micrograph of monkeypox virus particles (red/yellow/purple) found within an infected cell (green and blue)

Images of the newly identified H1N1 influenza virus taken in the CDC Influenza Laboratory. This preliminary negative stained transmission electron micrograph shows some of the ultrastructural morphology of the A/CA/4/09 swine flu virus

Yersinia pestis (Pasteurella pestis) is the bacterium responsible for bubonic plague. Optical microscopy X 2000.

This colorized negatively-stained transmission electron micrograph (TEM) captured some of the ultrastructural details exhibited by the new influenza A (H7N9) virus. On April 1, 2013, the World Health Organization (WHO) first reported 3 human infections with a new influenza A (H7N9) virus in China. Since then, additional cases have been reported. Most reported cases have severe respiratory illness and, in some cases, have died. At this time, no cases of H7N9 outside of China have been reported. This new H7N9 virus is an avian (bird) influenza (flu) virus. Human infections with avian influenza (AI, or bird flu) are rare but have occurred in the past, most commonly after exposure to infected poultry. However, this is the first time that this bird flu subtype (H7N9) has been found in people. This virus is very different from other H7N9 viruses previously found in birds.

2009 C. S. Goldsmith and A. Balish This preliminary negative stained transmission electron micrograph (TEM) depicted some of the ultrastructural morphology of the A/CA/4/09 swine flu virus. What is Swine Influenza Swine Influenza (swine flu) is a respiratory disease of pigs caused by type A influenza virus that regularly causes outbreaks of influenza in pigs. Swine flu viruses cause high levels of illness and low death rates in pigs. Swine influenza viruses may circulate among sw

This scanning electron microscope image shows SARS-CoV-2 (round yellow particles) emerging from the surface of a cell cultured in the laboratory. SARS-CoV-2, also known as 2019-nCoV, is the virus that causes COVID-19. Image captured and colorized at Rocky Mountain Laboratories in Hamilton, Montana. Credit: NIAID

Colorized transmission electron micrograph of mpox virus particles (red) found within an infected cell (green), cultured in the laboratory.

This colorized transmission electron micrograph (TEM) depicts numbers of influenza A virions while in their late passage growth phase.

Colorized transmission electron micrograph of avian influenza A H5N1 virus particles (orange), grown in Madin-Darby Canine Kidney (MDCK) epithelial cells (green).

Hepatitis C virus (HCV). Image produced from an image taken with transmission electron microscopy.

Coronavirus particles, illustration

Colorized transmission electron micrograph of monkeypox virus particles (orange) cultivated and purified from cell culture

Transmission electron microscopic image of a thin cross section cut through the isolated axoneme of Chlamydomanas reinhardtii, a unicellular flagellate

Colorized transmission electron micrograph of monkeypox virus particles (yellow) cultivated and purified from cell culture.

2009 C. S. Goldsmith and A. Balish This preliminary negative stained transmission electron micrograph (TEM) depicted some of the ultrastructural morphology of the A/CA/4/09 swine flu virus. See PHIL 11213 for a black and white version of this image. What is Swine Influenza Swine Influenza (swine flu) is a respiratory disease of pigs caused by type A influenza virus that regularly causes outbreaks of influenza in pigs. Swine flu viruses cause high levels of illness and low death r

This digitally-colorized transmission electron micrograph (TEM) depicts numerous Chikungunya virus particles, which are composed of a central dense core that is surrounded by a viral envelope. Each virion is approximately 50nm in diameter. Chikungunya virus is transmitted to people by mosquitoes. The most common symptoms of chikungunya virus infection are fever and joint pain. Other symptoms may include headache, muscle pain, joint swelling, or rash. Outbreaks have occurred in countries in Africa, Asia, Europe, and the Indian and Pacific Oceans. In late 2013, chikungunya virus was found for the first time in the Americas on islands in the Caribbean. Chikungunya virus is not currently found in the United States. There is a risk that the virus will be imported to new areas by infected travelers. There is no vaccine to prevent or medicine to treat chikungunya virus infection. Travelers can protect themselves by preventing mosquito bites. When traveling to countries with chikungunya virus,

Conceptual image of the Human Papilloma Virus (HPV). HPV is a virus from the papillomavirus family that affects human skin and the moist membranes that line the body.

Hepatitis C and polio virus particles, illustration

Electron Microscopy of a normal human cell. The cell membrane, nucleus and the nucleolus are all distinguishable.

Colorized transmission electron micrograph of monkeypox particles (purple) found within an infected cell (teal), cultured in the laboratory.

Influenza virus. Influenza A virus causes flu in humans, swine, birds, horses and dogs. Which species the virus will infect is determined by the glycoprotein spikes on its outer envelope. They are many strains of influenza A virus, among which the avian flu virus (H5N1), swine flu (H1N1) or human. Transmission Electron Micrograph (TEM).

Colorized transmission electron micrograph of mature extracellular Nipah virus particles (blue) near the periphery of an infected VERO cell (pink).

Coloured transmission electron micrograph (TEM) of a MERS coronavirus particle , this virus (originally novel coronavirus 2012) has been named Middle East respiratory syndrome (MERS) coronavirus.

Rickettsia rickettsii. Transmission electron micrograph (TEM) of Rickettsia rickettsii. This bacterium, causing the Rocky Mountain spotted fever observed in the Rocky Mountains (North America) and India, is transmitted to man with a tick (genus Dermacentor, Amblyomma and Haemaphysalis

Influenza virus. Image produced using high-dynamic-range imaging (HDRI) from an image taken with transmission electron microscopy. Viral diameter ranges from around 80 to 120 nm.

Apples, 2004, Andre Burian, (b.1966/Brazilian), Photograph

Transmission electron micrograph of dengue virus particles (green).

Group A streptococci pyogenes. It is the cause of skin infections (impetigo), abscesses, bronchopulmonary infections, a bacterial form of red angina which can develop into complications such as acute articular rheumatism. Optical microscopy X 1000.

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