Microscopic Tissue Analysis

Close-up microscopic images of various tissues, including skin and cancerous cells, revealing intricate textures and colors.

Scroll Coral, Night Fluorescing. Bonaire, Caribbean

Microscopic image of skin tissue.

As shown here, pancreatic cancer is associated with an extensive desmoplastic reaction in which the connective tissue around the tumor thickens and scars. Tests similar to the one described here can distinguish between and ampquotgood and ampquot and and ampquotbad and ampquot stromal reactions. The researchers hope this could enable the design of therapies that will reprogram the tumour-stroma interaction. Cancer cells are in red nuclei are in blue stroma / desmoplasia is in cyan and stroma-specific markers are yellow and green while marker overlays appear white.

Close up of Jewel Grouper skin Red Sea in Egypt

Bone spicules, marrow and adipose tissue

Natural occurring fluorescence in underwater red fluorescing sponge (Leucetta) and sea anemone (Macrodactyla), captured by using special UV blocking barrier filters, Night dive at Kalabahi Bay, Alor Island, Indonesia

This image shows the expression of keratin 5 (red) and keratin 1 (green) in skin tumors. Keratins are fibrous structural proteins found in epithelial structures, such as skin, hair, and nails. They form filaments that give strength and tenacity to structures. Keratins are often used to aid in the diagnosis of squamous cell carcinoma, a form of skin cancer.

Scroll Coral, Night Fluorescing. Bonaire, Caribbean

Pectoral fin of a Lunartail Grouper Red sea Egypt

Microscopy image of mouse sciatic nerves showing axons (red) enveloped by Schwann cells (green) with their nuclei shown in blue.

The image shows a cell culture of conditionally reprogrammed human breast cancer cells. The fluorescent red color represents MHC-I and the nuclei are shown in blue.

A new study in rats shows that stem cell secretions, called exosomes, appear to protect cells in the retina, the light-sensitive tissue at the back of the eye. The study was conducted by researchers from the National Eye Institute (NEI), which is part of the National Institutes of Health.

This image, winner of the Federation of American Societies for Experimental Biology's 2017 BioArt competition, shows the brain of an adult zebrafish, a popular organism for studying brain function. It captures dense networks of blood vessels (red) lining the outer surface of the brain. Next to many of these vessels are previously little-studied cells called fluorescent (yellowish-green) granular perithelial cells. Researchers now believe that these cells, often abbreviated as FGP, carry a lot like garbage cans that constantly absorb and store waste to keep the brain clean and functioning properly.

The parasitic worm that causes schistosomiasis hatches in water and grows into a freshwater snail, as shown here. Once mature, the worm returns to water, where it can infect people through skin contact. Initially, an infected person may have a rash, itchy skin, or flu-like symptoms, but the real damage is done over time to internal organs.

Angiography of myocardial infarction caused by atheromatous plaque in the right coronary artery. Angiographic visualization is produced by injection of contrast product.

The cerebellum from a GAD65-eGFP (green) transgenic mouse stained for calbindin to show Purkinje cells and DAPI (blue) to show nuclei.

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Cervical cancer. Squamous cell metaplasia seen by the microscopy of a histological section of the endocervical epithelium.

Uterine cancer visualized by sagittal MRI.

Night dive at Barrier Reef near Saint Georges Caye, Fluorescence emitted at night, exposed with special UV blocking filters, Belize, Central America

The image above shows a small section of the trachea, or windpipe, of a developing mouse. Although only the diameter of a pinhead at this stage of development, the mouse trachea has much in common structurally with the much wider and longer human trachea.

Natural occurring fluorescence in underwater red and green fluorescing hard coral (Oxpora lacera) and orange fluorescing Ostracods, captured by using special UV blocking barrier filters, Night dive at Kalabahi Bay, Alor Island, Indonesia

Pulmonary metastases (secondary to kidney cancer), visualized by chest CT scan in axial section. (Photo by: CAVALLINI JAMES/BSIP/UIG)

Natural occurring red fluorescing sponges (Leucetta sp.) and green hard coral (Acropora sp.). Night dive at Wetar Island, Banda Sea, Indonesia

Lily ovary, megaspores, magnification 400x, image enhanced

Close-up of a pattern

Lyme Disease Bacteria, Borrelia burgdorferi. The Lyme disease spirochete, Borrelia burgdorferi, is an obligate parasite that cycles between ticks and vertebrate hosts. B. burgdorferi alters the proteins expressed on its outer surface, depending on the state of each host. Here, we used immunofluorescent antibodies to identify spirochetes that express outer surface protein D (yellow and red) and merged the image with an image of all the spirochetes labeled with an anti-B. burgdorferi antibody (green).

Confocal microscope image of laser-induced choroidal neovascular complex (CNV) 14 days after laser injury. RPE-choroid flat mount (brown brown rat). The IB4 lectin (red) labels endothelial cells in the CNV complex. Phalloidin (green) labels f-actin in RPE junctional complexes and stress fibers. Cell nuclei are labeled with DAPI (blue).

Color-enhanced scanning electron micrograph of Vero E6 cells infected with Middle East respiratory syndrome coronavirus (MERS-CoV).

Stressed Over-Oxygenated Cells, Microscopic View

A human neutrophil (red) containing ingested Klebsiella pneumoniae (purple). NIH Investigates Multidrug-Resistant Bacterium Emerging in Community Settings

Vertebral osteitis (inflammation of the bone tissue of two dorsal vertebrae, caused by a bacterial infection). sagittal radiograph of the dorsal vertebrae

Natural occurring fluorescence in underwater hard coral (Diploastrea heliopora). Night dive near Lewolin Village, Illi Api Island, Selat Boleng Strait, Indonesia

Far being shone nebula and star field against space. Elements of this image furnished by NASA . 3D rendering.. Far being shone nebula and star field. 3D rendering

Influenza virus of the Orthomyxoviridae family (respiratory viral infection). Transmission electron microscopy, viral diameter 80 to 120 nanometers.

Comparing Mutant Cell and Normal Cell, Microscopic View

Shape of bacterial cell: cocci, bacilli, spirilla bacteria background

Hair cells (red) and associated supporting cells (green) in the sensory patch of a mouse utricle, part of the balancing apparatus of the inner ear.

Ebru marbling handmade art, traditional Ebru technique. abstract background of marble liquid ink art

This image shows mouse muscle cells seen under a microscope. The cells have fused to form myotubes which have many nuclei (stained blue). The cells produced from mouse skeletal muscle stem cells with a harmless virus that made them glow green. The green color remained when the stem cells fused into myotubes. Some myotubes are stained red for a protein involved in muscle contraction (myosin heavy chain), a characteristic of mature muscle fibers. Researchers should use the same viral delivery system to genetically modify cells and assess how altering cell fusion impairs myotube growth. This image was the 2017 winner of the Federation of American Societies for Experimental Biology (FASEB) BioArt competition.

Colorized transmission electron micrograph of two mature mpox virus particles (yellow) attached to the surface of an infected VERO E6 cell (purple/pink).

Large prostatic adenoma, visualized by frontal x-ray of the pelvis.

The human coronavirus causes respiratory infections (colds), and gastroenteritis. Image made from a transmission electron microscopy view. Approximate viral diameter: 80 to 160 nm.

Prion protein shown in E. coli, purified and fibrillated at pH 7. Recombinant proteins such as the prion protein shown here are often used to model how proteins respond to each other and sometimes polymerize in neurodegenerative disorders.

The optical properties (color, intensity) of minerals such as azurite and malachite are explained in the context of conventional electronic spectroscopy of coordination complexes. Relatively detailed descriptions are proided by ligand field theory.

Dendritic cells entering the hair follicle. Credit: NIAID

Air and oil bubbles inside water base form patterns

Researchers study star-shaped brain cells: NIH-funded researchers have used 3D collections of brain tissue from human cells to study star-shaped astrocytes in the brain.

Cancer of the uterus. Adeno-acanthoma (glandular tumor). Cancer of the endometrium develops from the membrane lining the uterus. Microscopy of a histological section.

Transmission electron micrograph of Ebola virus nucleocapsids (small orange circles) and virus particles (larger orange filamentous shapes) in infected African green monkey kidney cells. Focused image at the NIAID Integrated Research Center in Fort Detrick, Maryland.

Prion-like Aggregating Protein in a Cell, Microscopic View

Under 50X magnification, this image shows a section of skin tissue, taken from a lesion on the skin of a monkey infected with monkeypox virus. The specimen was obtained on day 8 of rash development.

Dorsal Root Ganglion neuron growth cones

Italy, Sicily, Mt Etna Lava. The dark of night intensifies the dramatic color of flowing lava from Mt. Etna on Sicily in Italy.

Avian influenza H5N1 virus

Colorized transmission electron micrograph of mpox virus particles (orange) found within an infected cell (brown and green), cultured in the laboratory.

Arteritis of the lower limbs (disease affecting the arteries of the legs, it is almost always due to a deposit of cholesterol in the arteries, which limits blood circulation). microscopy on a histological section of a diseased artery.

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Small intestine small intestine pig crossing 100x copyright: xzoonar.com/dr.xnorbertxlangex 13693893

Cells in the hilus of the dentate gyrus of the hippocampal formation from an Nr4a1-eGFP (green) transgenic mouse stained for calretinin (red) and DAPI (blue) to show nuclei.

Rotavirus-infected cell revealing numerous viral factories in the cytoplasm.

This image captures the many layers of nerve cells in the retina. The top (green) layer is made up of cells called photoreceptors that convert light into electrical signals to send to the brain. The two most well-known types of photoreceptor cells are rod-shaped and cone-shaped. Rods help us see in low light conditions, but can and

Transmission electron microscopic image of microvilli from a human epithelial cell in the jejunum of the small intestine

Natural occurring fluorescence in underwater orange fluorescing tunicates (Botryllus) and green hard coral (Acropora), captured by using special UV blocking barrier filters, Night dive at Wetar Island, Banda Sea, Indonesia

An NIH-funded mouse study suggests scar formation may help, not hinder, nerve regrowth.

Cell death in limb bud of a webbed foot

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In addition to blood vessels (red) and nerve cells (green), this mouse brain has abnormal clumps of proteins called plaques (blue). These plaques multiply in the brains of people with Alzheimer's disease and

Light micrograph cross section through the young fruit of a Tomato plant (Lycopersicum esculentum) CS, UK

Frontal upper gastrointestinal (GI) series.

Cancer of the liver, seen in a radial cross-section abdominal scan

Microscopy of a spinal cord sample from a mouse model of neurodegeneration. The following fluorescent stains are used: DAPI is blue, TDP-43 is green, and GFAP is red. Researchers from the Developmental Neurodegeneration Unit at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) are using these models to study the early events that underlie the onset and progression of neurodegenerative diseases, such as amyotrophic lateral sclerosis and Parkinson's disease.

Nerve cell under the microscope - Abstract blue dots on white background.

Pulmonary embolism in the left and right pulmonary arteries, seen on a radial section chest CT scan.

Compact bone, light micrograph. Compact bone consists of concentric layers of collagen_containing matrix lamellae, dark blue, around Haversian canals ...

tinsel for decorating a Christmas festive tree. computer processing, inversion. tinsel for decorating a Christmas festive tree. computer processing, inversion Copyright: xZoonar.com/OvchinnikovaxOlgax 11565235

Nerve fibres. Light micrograph (LM) of a transverse section through a bundle (fascicle) of nerve fibres. Within each fascicle are many myelinated nerv...

Aerial view of molten lava flowing like a fiery river through the dark, rugged volcanic landscape, Reykjavík, Reykjavíkurborg, Iceland.

The ability of cancer cells to move and spread depends on central actin-rich structures such as podosomes (yellow) shown here in melanoma cells. Cell nuclei (blue), actin (red) and an actin regulator (green) are also shown.

Ebola virus isolated in November 2014 from patient blood samples obtained in Mali. The virus was isolated on Vero cells.

Ebru marbling handmade art, traditional Ebru technique. abstract background of marble liquid ink art

Purkinje nerve cells, LM

This sagittal MRI image of the thoracic spine reveals a spondylodiscitis.

Colorized transmission electron micrograph of monkeypox particles (green) found within an infected cell (pink and purple), cultured in the laboratory.

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Allergic bronchopulmonary aspergillosis (ABPA), seen on a frontal chest x-ray.

Hair follicles, light micrograph

Colorized transmission electron micrograph of monkeypox virus particles (green) found within an infected cell (orange), cultured in the laboratory.

jsc2019e039825 (7/16/2019) --- Preflight Ffuorescence microscopy image of biofilm of Spingomonas desiccabilis growing over and into the surface of a basalt slide as part of BioRock experiment. Organisms are stained with DNA binding sye Sybr Gold. Growth can be seen into the rock cavities. The purpose of the Biorock investigation is to examine the effects of altered gravity on the rock/microbe/liquid system as a whole. (Image Courtesy of: ESA)

Light micrograph longitudinal section through the fruit pedicel of a Tomato plant (Lycopersicum esculentum) LS, UK.

Genetically Engineered Cell, Microscopic View

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Microscopic image of mitochondria in a single heart cell. Mitochondria highlighted in red were exposed to ultraviolet light.

Cancer of the right kidney visualized by an abdominal scanner in radial section. (Photo by: CAVALLINI JAMES/BSIP/UIG)

Cancer of the right kidney visualized by an abdominal scanner in radial section.

Microglia, a type of nervous system cell previously suspected of causing retinal damage, has been shown to be beneficial in slowing the progression of prion disease in the brain, and now in the retina. In this image, microglial cells (green) engulf and remove prion-damaged photoreceptors (red), which appears to slow retinal degeneration.

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